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Anti-Fibroticadvanced tier

TB-500

Thymosin Beta-4

Reduce scalp fibrosis, restore follicle health

Overview

TB-500 is a synthetic version of the naturally occurring Thymosin Beta-4 peptide. In the context of hair loss, its primary role is combating the scalp fibrosis and chronic inflammation that progressively suffocate follicles in androgenetic alopecia. It also promotes cell migration, a key process in follicle cycling.

Mechanism of Action

Sequesters G-actin to modulate cytoskeletal dynamics. Upregulates MMP-2 to remodel excess extracellular matrix (fibrosis) around follicles. Anti-inflammatory via downregulation of NF-κB and pro-inflammatory cytokines (IL-1β, TNF-α).

Pathway

MMP-2 + NF-κB modulation

Key Benefits

Softens hardened, fibrotic scalp tissue
Reduces chronic low-grade scalp inflammation
Improves cellular migration in follicle cycling
Systemic recovery benefits (joints, muscle)
Long half-life — twice-weekly dosing sufficient

Protocol

Dose

2.0–2.5 mg

Frequency

Twice weekly

Duration

8–12 weeks

Method

Subcutaneous injection

Research Evidence

Published Studies

40+

Key Finding

Significant reduction in scalp fibrosis markers

Source TB-500

$59.99

per vial · research grade

Shop TB-500

≥98% purity · COA available · Research use only

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