IGF-1 LR3
Insulin-like Growth Factor
Direct anabolic stimulus for hair follicle cells
Overview
IGF-1 LR3 is a long-acting version of Insulin-like Growth Factor 1 with an arginine substitution that prevents IGF binding protein attachment. In hair biology, IGF-1 is produced by dermal papilla cells in response to growth hormone and directly stimulates follicle keratinocyte proliferation.
Mechanism of Action
Binds IGF-1R on outer root sheath and matrix cells, activating PI3K/AKT/mTOR proliferative cascade. Dermal papilla cells are a key source of paracrine IGF-1, and their atrophy in AGA is a major driver of miniaturization.
PI3K/AKT/mTOR via IGF-1R on follicle cells
Key Benefits
Protocol
Dose
20–40 mcg
Frequency
Daily
Duration
4–6 weeks (cycle)
Method
Subcutaneous injection
Research Evidence
Published Studies
30+
Key Finding
IGF-1 deficiency directly correlates with AGA severity
Source IGF-1 LR3
$79.99
per vial · research grade
Shop IGF-1 LR3≥98% purity · COA available · Research use only
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